Antibiotics Mechanism

Antibiotics Mechanisms Review,, keep sharing :)
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Vancomycin Mechanism Inhibits cell wall peptidoglycan formation/binds D-ala D-ala
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Macrolides Mechanism 50S Translocation inhibition
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Lincosamide/Clindamycin Mechanism 50S Translocation inhibition
.
Chloramphenicol Mechanism 50S Blocks peptidyl transferase
.
Tetracyclines Mechanism 30S A site blocking
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Linezolid Mechanism 50S Blocks initiator tRNA binding/ribosome formation
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Aminoglycosides Mechanism 30S initiation complex formation
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Sulfonamides Mechanism PABA antimetabolites (at dihydropteroate synthase PABA to DHPA)
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Trimethoprim Mechanism PABA antimetabolites (at dihydrofolate reductase DHF to THF)
.
Pyrimethamine Mechanism PABA antimetabolites (at dihydrofolate reductase DHF to THF)
.
Fluoroquinolones Mechanism Inhibit DNA topoisomerase II/IV (II is gyrase)
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Metronidazole Mechanism Forms free radical toxic metabolites that damage DNA
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Isoniazid Mechanism Decrease synthesis of mycolic acids
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Rifampin Mechanism Inhibits DNA dependent RNA polymerase
.
Pyrazinamide Mechanism Uncertain/thought to acidify intracellular
compartments where TB is engulfed
.
Ethambutol Mechanism Block arabinosyltrasnferase/stops carbohydrate polymerization in myobacteria